Peripheral Regulation of Energy Metabolism by Thyroid Hormones
نویسندگان
چکیده
Thyroid hormone is long known as an important regulator of metabolism. It exerts general effects such as increased cycling of metabolites and stimulation of ATP turnover in spite of reduced efficiency of oxidative phosphorylation, but also very specific effects in peripheral tissues. This article reviews the most relevant metabolic effects of thyroid hormone in peripheral tissues, including the specific contributions of the two different thyroid hormone receptor isoforms. Special focus is put on the thermogenic effects of thyroid hormone in muscle and brown adipose tissue as well as the exclusive role of the thyroid hormone receptor β in hepatic cholesterol metabolism.
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